Chemotherapy of murine leprosy. V. The effects of various combinations of 4, 4 -diaminodiphenyl sulfone (DDS), streptomycin and isoniazid on mouse leprosy.

Chemotherapy of murine leprosy. II. The effects of streptomycin, sulfones and isonicotinylhydrazines on mouse leprosy.

The effectiveness of the sulfones in the treatment of human leprosy is well known (9, 11). The antileprosy activity of streptomycin has been reported by several workers (6, 9, 11, 18). However, the action of these drugs on murine leprosy is stilI not established. Prom in has been reported to have an inhibitory action on rat leprosy (2, 5) and on mouse leprosy (8). Diasone has been considered ef...

Biochemical and ultrastructural study of the relationship between lysosomal enzyme activities and chemotherapy.

One of th e ultrastructural charac teristics of lepra cells in human leprosy is the occurrence of opaque droplets around the bacilli (D. 12) . Electron microscopic cytochemistry showed tha t these droplets contain acid phosphatase, and consequently they were named "lysosomal substances" (10) . In addition it was observed that chemotherapy, especially with DDS, elicits the formation of the lysos...

Sundry experiences in the chemotherapy of leprosy.

Experience with sulfone treatment of leprosy at Uzuakoli, Nigeria, during the last four years has been described by Davey (1), Lowe and Smith (5), Smith (6, 7) and Lowe (3, 4), and further reports are now ready for publication. There are, however, sundry points which have not been mentioned in these publications, or mentioned only in passing, and which may be of interest to leprosy workers. In ...

Antimalarial studies on 4,4-diaminodiphenyl sulfone (DDS) and repository sulfones in experimental animals.

Clinical Evaluation of Isonicotinic Acid Hydrazide as an Adjuvant in the Treatment of Lepromatous Leprosy

A clinical evaluation study of diasone, diaminodiphenyl sulfone (DDS) and dihydrostreptomycin (DHSM) separately, conducted in four institutions including Westfort, has been reported by Doull (2). The present evaluation study of the effects of isonicotinic acid hydrazide (isoniazid, INH) and of streptohydrazid on lepromatous leprosy, continued over a period of two years from September 1953 to Se...